Candid Summaries on CBD Studies

Inflammation: Anti-Inflammatory Effect of CBD on Canine Models of Inflammation

KEY TAKEAWAYS:

  • TNF-α is a proinflammatory molecule with increased expression and present in high pathological levels in canine atopic dermatitis
  • IL-6 (proinflammatory molecule) production is boosted in atopic dermatitis and its blockage can help improving this disease
  • Both TNF-α and IL-6 are associated with the pathogenesis of arthritis in dogs 
  • CBD reduced the secretion of TNF-α and IL-6 (molecules that drive the inflammatory response) in an ex vivo model of inflammation in canine blood cells
  • The TNF-α to IL-10 (pro-inflammatory molecule) ratio is a marker of the balance between key pro- and anti-inflammatory levels
  • Treatment with CBD restored the TNF-α to IL-10 ratio to a healthy balance 
  • CBD also reduced NF-κB activation (NF-κB is a regulator of the inflammatory response and of many pro-inflammatory cytokines)
  • Finally, administration of CBD to the inflamed cells resulted in a lower COX-2 (which is upregulated in inflammation) expression 
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Skin: CBD Modulates the Regulation of Inflammatory Genes Related to Canine Atopic Dermatits

KEY TAKEAWAYS:

  • Canine atopic dermatitis (AD) is a multifactorial allergic disease that affects up to 27% of dogs and is associated with immune dysfunction and abnormal skin barrier
  • Due to elevated costs and side effects of traditional medication, natural treatments are constantly being developed
  • Cannabidiol was able to downregulate key actors involved in the development and progression of this dermatological disease
  • Treatment with CBD + polyphenols showed an ability to revert the overexpression of canine AD key inflammatory genes
  • This study’s results provide groundwork for CBD application in sustained drug therapy or relapse prevention in atopic dermatitis
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Grooming: Hair Regrowth after Treatment with Topical CBD

KEY TAKEAWAYS:

  • The endocannabinoid system participates in skin equilibrium via CB1 and CB2 and TRPV receptors
  • Pre-clinical studies illustrate evidence of the hair regrowth benefits of antagonizing the CB1 receptors and over stimulating TRPV1 with CBD
  • CBD has also been shown to result in hair elongation and to maintain the hair follicle in the growing phase of the hair cycle
  • The study showed a 93.5% increase in nonvellus (new) hair after six months of treatment with topical CBD
  • No side effects were reported 
  • Growth of new hair it’s a way of reviving and replacing the damaged hair in your dog's fur
  • New hair is healthier, shinier and softer than old damaged hair, since it hasn't been in contact with the harmful stimuli of the environment 
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Skin: Studying the Distribution of Cannabinoids Receptors in Dogs with Atopic Dermatitis

KEY TAKEAWAYS:

  • CBD is a cannabinoid whose effects are exerted via two types of receptors, CB1 and CB2 that take part in the endocannabinoid system 
  • The endocannabinoid system may be a target for treatment of immune-mediated and inflammatory disorders such as allergic skin diseases in dogs
  • Dermatitis is a major medical issue in the field of veterinary medicine, and atopic dermatitis (AD) a common condition in dogs; no single treatment is universally effective.
  • The cannabinoid receptors are overexpressed in AD, making them a target for treatment
  • This study reports that cannabinoids, such as CBD, can be a treatment option for AD and other inflammatory diseases in companion animals
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Safety: Administering CBD Did Not Affect Canine Daily Voluntary Activity

KEY TAKEAWAYS:

  • Oral CBD administration didn’t alter the overall activity in adult dogs
  • Contrary to reports on possible sedative and hypnotic effects of CBD, this study didn’t confirm any of these claims
  • Administration of CBD reduced scratching duration, highlighting a benefit in its use to treat skin diseases and pruritic disorders
  • No adverse events were observed in any dogs following CBD administration 
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