Candid Summaries on CBD Studies

Anxiety: CBD as an Anxiety Treatment

KEY TAKEAWAYS:

  • Preclinical evidence strongly supports the potential of CBD as a treatment for anxiety 
  • In dogs, anxiety is responsible for depression, aggressiveness, restlessness and destructive and compulsive behaviors; it also impacts dogs’ quality of life in a significant and negative way
  • Cats have similar anxiety-related behaviors, with restlessness, trembling, aggression and decreased appetite being the most worrying problems. Isolation and anti-social attitudes are also common
  • 68.75% of the studies reviewed demonstrated the anxiolytic effects of CBD
  • CBD reduced experimentally-induced anxiety in healthy subjects and reduced anxiety in patients with social anxiety disorders (SAD)
  • Systemically administered CBD reduced acute increases in heart rate and blood pressure produced by states of heightened anxiety
  • CBD blocked reconsolidation of unpleasant memories in rats and enhanced extinction of fear memories in healthy humans
  • Human experimental studies put into evidence CBD’s excellent safety profile and minimal sedative effects
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Anxiety: CBD May Reduce Aggressive Behaviour Towards Humans in Shelter Dogs

KEY TAKEAWAYS:

  • After CBD administration, aggressive behavior towards humans showed a significant decrease 
  • Fear and anxiety are a common cause of aggressive conducts in dogs 
  • Dogs in the study did not show any of the symptoms referable to CBD intolerance
  • CBD treatment did not decrease the activity nor level of attention towards the environment of the dogs studied, as already highlighted for other species 
  • The positive outcomes in this defiant environment are promising for more friendlier ones 
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Anxiety: Cannabidiol in Anxiety and Sleep: A Large Case Series

KEY TAKEAWAYS:

  • 79.2% of the patients exhibited an improvement in anxiety in the 1st month 
  • The decrease of anxiety levels was sustained during the rest of the treatment period
  • 66.7% of the population experienced less sleep-related problems in the 1st month
  • The mean anxiety score dropped from 23.87 to 16.36 in the population whose primary concern was anxiety
  • The patients presenting with a primary concern of sleep had a reduction from 13.08 to 9.33 in the mean sleep-problems score
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Candid CBD study on Anxiety and Stress

KEY TAKEAWAYS:

  • CBD can prevent the long-lasting anxiogenic effect promoted by traumatic events
  • When compared to the control group, the reduction in anxiety behavior was greater with CBD than with the common antidepressant used in PTSD treatment
  • CBD anti-stress effects could depend on serotonin (5HT1A) receptor activation; serotonin contributes to the feeling of well-being, reason why it’s often labeled happiness hormone
  • The study suggest CBD has beneficial potential for the treatment of PTSD
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